Medical News
Latest News on Primary Aldosteronism
- Synergistic interplay between cortisol and aldosterone: unveiling mechanisms of vascular calcification in hyperaldosteronism December 20, 2024Hypertension Research - Synergistic interplay between cortisol and aldosterone: unveiling mechanisms of vascular calcification in hyperaldosteronismChih-Yuan WangHorng-Yih Ou
- The relationship between tissue inhibitor of metalloproteinases-1 and KCNJ5 mutation in aldosterone-producing adenoma patients December 17, 2024Hypertension Research - The relationship between tissue inhibitor of metalloproteinases-1 and KCNJ5 mutation in aldosterone-producing adenoma patientsNature
- A Case of Primary Aldosteronism Masquerading as Bartter and Gitelman Syndromes December 13, 2024Primary aldosteronism (PA) is a common cause of secondary hypertension, with familial hyperaldosteronism (FH) contributing to a lesser number of cases. FH type IV, a rare subtype, has hardly bee...cureusinc
- Hypokalemia-Induced Rhabdomyolysis Secondary to Adrenal Adenoma: A Case Report December 3, 2024Adrenal adenoma, which leads to increased production of the hormone aldosterone, commonly presents as hypertension and hypokalemia. Rhabdomyolysis as a result of hypokalemia secondary to primary...cureusinc
- Water and Electrolyte Content in Hypertension in the Skin (WHYSKI) in Primary Aldosteronism December 1, 2024BACKGROUND: Primary aldosteronism (PA), the most common curable salt-dependent form of arterial hypertension, features renal K+ loss and enhanced Na+ reabsorption. We investigated whether the electrolyte, water, and TonEBP (tonicity-responsive enhancer binding protein)/NFAT5 (nuclear factor of activated T cells 5) content is altered in the skin of patients with PA and corrected by surgical cure. […]Hypertension
- Circulating miRNAs and Machine Learning for Lateralizing Primary Aldosteronism December 1, 2024BACKGROUND: Distinguishing between unilateral and bilateral primary aldosteronism, a major cause of secondary hypertension, is crucial due to different treatment approaches. While adrenal venous sampling is the gold standard, its invasiveness, limited availability, and often difficult interpretation pose challenges. This study explores the utility of circulating microRNAs (miRNAs) and machine learning in distinguishing between unilateral […]Hypertension
- Evolution of mineralocorticoid receptor antagonists, aldosterone synthase inhibitors, and alternative treatments for managing primary aldosteronism November 29, 2024Hypertension Research - Evolution of mineralocorticoid receptor antagonists, aldosterone synthase inhibitors, and alternative treatments for managing primary aldosteronismYuichi YoshidaHirotaka Shibata
PA Foundation in the News
- Primary Aldosteronism AllianceIn September 2022, the PA Foundation announced the creation of a multistakeholder alliance to drive diagnosis and treatment of primary aldosteronism.
- Dietary Sodium Global Call to ActionThe PA Foundation is one of the co-authors of the World Hypertension League’s call to action published in May 2022 by the Journal of Human Hypertension.
- BMJ Practice Series: Easily Missed?The PA Foundation co-authored the article of the BMJ Practice Series on primary aldosteronism. The open access article was published in April 2022.
- Doctors Overlook a Curable Cause of High BPMIT’s magazine, Undark, featured the PA Foundation in an article of its February 2022 edition dedicated to primary aldosteronism.
Notable Publications of the Year
Primary Aldosteronism in the EROver 40% of patients presenting to the ER of an Australian tertiary health network met the criteria for PA testing. Only 2% were screened.
BPA and Primary Aldosteronism ScreeningImplementation of an EHR best-practice advisory yielded a screening rate of 14%. Most orders were placed by internists (40%) and primary care physicians (28%).
AVS and Asymmetrical Bilateral PAMultifocal, asymmetrical bilateral PA cannot be excluded by robust AVS lateralization. The study’s independent predictors of postoperative residual PA included Black race, AVS lateralization only at baseline, and CT-AVS disagreement.
68Ga-Pentixafor PET/CT and Subtyping of PAIn a study of 123 patients with adrenal micronodules, the sensitivity, specificity, and accuracy of 68Ga-pentixafor PET/CT in subtyping primary aldosteronism were 90.2%, 86.3%, and 89.4%, respectively. The accuracy of AVS examination was lower than that of PET/CT.
Latest News on Hypertension
- Belapectin Misses Primary Endpoint in Phase 3 MASH Cirrhosis, Portal Hypertension Trial December 20, 2024The phase 2b/3 NAVIGATE trial missed its primary endpoint for the prevention of varices in patients with MASH cirrhosis and portal hypertension.Abigail Brooks, MA
- The Target BP Intiative: Aiming to Improve Hypertension Care for All December 20, 2024As prevalence of CVDs continues to increase, the AHA and AMA have developed the Target BP initiative to improve blood pressure control in US adults.Meahjabeen Hoque
- We Can Fight Chronic Disease with Universal Care December 20, 2024It’s time for the United States to join other high-income nations in providing comprehensive health coverage to all its citizens.Cristiana Baloescu
- Trial finds planned early term birth helps to avoid complications in women with high blood pressure December 20, 2024A Birmingham Clinical Trials Unit trial finds investigates planned early term birth for those with hypertension in pregnancy.University of Birmingham
- Home monitoring helps moms track blood pressure after birth, reducing risks December 20, 2024High blood pressure disorders affect one in seven patients during pregnancy or after delivery, leading to an increased risk of dangerous complications that can include stroke, heart failure and seizures.Erica Zurek
- Idorsia’s sale of Tryvio falls behind schedule, but layoffs remain on track December 20, 2024Idorsia’s plans to sell its hypertension drug Tryvio haveJames Waldron
