Medical News
Latest News on Primary Aldosteronism
- Integrative bioinformatics approach identifies novel drug targets for hyperaldosteronism, with a focus on SHMT1 as a promising therapeutic candidate January 11, 2025Scientific Reports - Integrative bioinformatics approach identifies novel drug targets for hyperaldosteronism, with a focus on SHMT1 as a promising therapeutic candidateAuthor notesMinyue JiaLiya LinHanxiao YuZhichao DongXin PanXiaoxiao Song
- Evolutionary Characteristics in Primary Aldosteronism Patients January 1, 2025BACKGROUND: Primary aldosteronism is predominantly caused by excessive aldosterone production from the adrenal cortex, and the aldosterone-producing structures could take many forms, like adenomas, nodules, micronodules, and so on. Most studies of primary aldosteronism were limited to the hotspot driver genes responsible for autonomous aldosterone production; however, the panoramic genetic architecture and genomic alterations of […]Hypertension
- An Atypical Case of Licorice-Induced Pseudoaldosteronism Presenting With Decreased Urine Potassium Excretion in the Presence of Severe Hypokalemia in a Very Elderly Patient December 31, 2024Most herbal medicines contain licorice, which may inhibit 11-beta-hydroxysteroid dehydrogenase type 2 (11βHSD2). When licorice inhibits 11βHSD2, accumulated cortisol binds excessively to the min...cureusinc
- Possible antihypertensive effects of mineralocorticoid receptor antagonists other than reducing extracellular water December 24, 2024Hypertension Research - Possible antihypertensive effects of mineralocorticoid receptor antagonists other than reducing extracellular waterRyutaro MoritaHiromichi WakuiKouichi Tamura
- Synergistic interplay between cortisol and aldosterone: unveiling mechanisms of vascular calcification in hyperaldosteronism December 20, 2024Hypertension Research - Synergistic interplay between cortisol and aldosterone: unveiling mechanisms of vascular calcification in hyperaldosteronismChih-Yuan WangHorng-Yih Ou
- The relationship between tissue inhibitor of metalloproteinases-1 and KCNJ5 mutation in aldosterone-producing adenoma patients December 17, 2024Hypertension Research - The relationship between tissue inhibitor of metalloproteinases-1 and KCNJ5 mutation in aldosterone-producing adenoma patientsNature
- A Case of Primary Aldosteronism Masquerading as Bartter and Gitelman Syndromes December 13, 2024Primary aldosteronism (PA) is a common cause of secondary hypertension, with familial hyperaldosteronism (FH) contributing to a lesser number of cases. FH type IV, a rare subtype, has hardly bee...cureusinc
PA Foundation in the News
- Primary Aldosteronism AllianceIn September 2022, the PA Foundation announced the creation of a multistakeholder alliance to drive diagnosis and treatment of primary aldosteronism.
- Dietary Sodium Global Call to ActionThe PA Foundation is one of the co-authors of the World Hypertension League’s call to action published in May 2022 by the Journal of Human Hypertension.
- BMJ Practice Series: Easily Missed?The PA Foundation co-authored the article of the BMJ Practice Series on primary aldosteronism. The open access article was published in April 2022.
- Doctors Overlook a Curable Cause of High BPMIT’s magazine, Undark, featured the PA Foundation in an article of its February 2022 edition dedicated to primary aldosteronism.
Notable Publications of the Year
Primary Aldosteronism in the EROver 40% of patients presenting to the ER of an Australian tertiary health network met the criteria for PA testing. Only 2% were screened.
BPA and Primary Aldosteronism ScreeningImplementation of an EHR best-practice advisory yielded a screening rate of 14%. Most orders were placed by internists (40%) and primary care physicians (28%).
AVS and Asymmetrical Bilateral PAMultifocal, asymmetrical bilateral PA cannot be excluded by robust AVS lateralization. The study’s independent predictors of postoperative residual PA included Black race, AVS lateralization only at baseline, and CT-AVS disagreement.
68Ga-Pentixafor PET/CT and Subtyping of PAIn a study of 123 patients with adrenal micronodules, the sensitivity, specificity, and accuracy of 68Ga-pentixafor PET/CT in subtyping primary aldosteronism were 90.2%, 86.3%, and 89.4%, respectively. The accuracy of AVS examination was lower than that of PET/CT.
Latest News on Hypertension
- Hypertension risk assessment may be improved by ECG-based AI January 20, 2025An electrocardiography-based artificial intelligence risk estimator for hypertension may help to identify patients with an increased risk of developing hypertension and its adverse outcomes.Lucy Piper
- This "Silent Killer" Disease Has Targeted Nearly Half Of US Adults January 20, 2025Nearly half of American adults have hypertension, and more than 1 in 10 have diabetes, according to a wellness expert.NDTV News Desk
- Mineralys Therapeutics (MLYS): Lorundrostat Is Worth A Shot In 2025 For Hypertension January 20, 2025Mineralys Therapeutics has a promising candidate with Lorundrostat for hypertension, CKD, and OSA. Read why I feel MLYS stock is a good speculative Buy.Myriam Alvarez
- Association of nighttime very short-term blood pressure variability determined by pulse transit time with adverse prognosis in patients with heart failure January 20, 2025Hypertension Research - Association of nighttime very short-term blood pressure variability determined by pulse transit time with adverse prognosis in patients with heart failureNature
- Soluble guanylate cyclase stimulators and activators as potential antihypertensive drugs January 20, 2025Hypertension Research - Soluble guanylate cyclase stimulators and activators as potential antihypertensive drugsMasashi TawaKeisuke NakagawaMamoru Ohkita
- Association of the triglyceride glucose index with obesity indicators and hypertension in American adults based on NHANES 2013 to 2018 January 19, 2025Scientific Reports - Association of the triglyceride glucose index with obesity indicators and hypertension in American adults based on NHANES 2013 to 2018Nature
