The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being administered to children per SOC as prescribed by their treating provider.
Clinical Study
Summary
Study Name: Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care
Status: Unknown
Conditions: More than 25 conditions including hypertension and primary aldosteronism
Interventions: Drug: This study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
Locations: Phoenix Children’s Hospital, Phoenix, AZ; Arkansas Children’s Hospital Research Institute, Little Rock, AR; University of California, Los Angeles, CA; Lucile Packard Children’s Hospital, Palo Alto, CA; Colorado University Denver, Aurora, CO; DuPont Hospital for Children, Wilmington, DE; Jacksonville Shands Medical Center, Jacksonville, FL; Kapiolani Womens and Childrens Medical Center, Honolulu, HI; Ann and Robert Lurie Childrens Hospital of Chicago, Chicago, IL; Riley Hospital for Children at Indiana University, Indianapolis, IN; University of Iowa Stead Family Children’s Hospital, Iowa City, IA; University of Louisville Norton Childrens Hospital, Louisville, KY; Ochsner Baptist Clinical Trials Unit, New Orleans, LA; University of Maryland Medical Center, Baltimore, MD; Boston Children’s Hospital, Boston, MA; Massachusetts General Hospital, Lexington, MA; University of Minnesota, Minneapolis, MN; University of Mississippi, Jackson, MS; Mississippi Center for Advanced Medicine, Madison, MS; Childrens Mercy Hospital, Kansas City, MO; University of Nebraska Medical Center, Omaha, NE; University of New Mexico Health Science Center, Albuquerque, NM; University of North Carolina, Chapel Hill, NC; Durham University Health System, Durham, NC; Cincinnati Childrens Hospital Medical Center, Cincinnati, OH; Board of Regents of the University of Oklahoma, Oklahoma City, OK; Oregon Health and Science University, Portland, OR; Hershey Children’s Hospital, Hershey, PA; Medical University of South Carolina, Charleston, SC; University of South Carolina, Columbia, SC; Avera McKennan Hospital & University Medical Center, Sioux Falls, SD; Children’s Hospital at Vanderbilt, Nashville, TN; Dell Children’s Medical Center of Central Texas, Austin, TX; University of Texas-Southwestern Medical Center, Dallas, TX; University of Texas – Memorial Hermann Texas Medical Center, Houston, TX; Seattle Children’s Hospital, Seattle, WA; West Virginia University Hospital, Morgantown, WV; University of Wisconsin, Madison, WI; Medical Center of Wisconsin, Milwaukee, WI; Children’s Hospital of Eastern Ontario, Ottawa, Ontario, Canada; The Hospital for Sick Children, Toronto, Ontario, Canada; CHU Sainte-Justine, Montreal, Quebec, Canada
Study link: https://clinicaltrials.gov/study/NCT04278404
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