The investigators hypothesize that in patients with primary aldosteronism, increased aldosterone levels induce microvascular dysfunction through reduction of NO-availability, which contributes to the development of insulin resistance, and of hypertension, in addition to the sodium-retaining effects of aldosterone.
Clinical Study
Summary
Study Name: Microvascular Function in Patients With Primary Aldosteronism and Essential Hypertension
Status: Withdrawn
Conditions: Primary aldosteronism, Essential hypertension
Interventions: Procedure: Adrenal extirpation; Drug: Antihypertensive medication
Locations: Maastricht University Medical Center, Maastricht, Netherlands
Study link: https://clinicaltrials.gov/study/NCT02096939
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